The fourth inning started out badly: Brett Lawrie was taken out of the game with back tightness, and Mark Buehrle had an extended inning that started with back-to-back homers and later followed by three singles, including a turf single that hopped away from new third baseman Danny Valencia. However, Colby Rasmus responded by hitting a two-run homer in the bottom half to make it 4-2.
Buehrle now gives way to Aaron Sanchez after tossing 96 pitches over the first four.